| 英文品名 |
citatuzumab bogatox |
| 名称来源 |
p-INNList-99,2008;r-INNList-61,2009; |
| 化学表述 |
immunoglobulin Fab fusion protein, anti-[Homo sapiens tumorassociatedcalcium signal transducer 1 (TACSTD1, gastrointestinaltumor-associated protein 2, GA733-2, epithelial glycoprotein 2, EGP-2, epithelial cell adhesion molecule Ep-CAM, KSA, KS1/4 antigen,M4S, tumor antigen 17-1A, CD326)], humanized Fab fused withBougainvillea spectabilis Willd rRNA N-glycosidase [type I ribosomeinactivating protein (RIP), bouganin], VB6-845; gamma1 heavy chainfragment (1-225) [hexahistidyl (1-6) -humanized VH from 4D5MOC-B(Homo sapiens FR/Mus musculus CDR, Homo sapiens IGHJ4*01,V124>L) [8.8.9] (7-122) -Homo sapiens IGHG1*01 CH1-hingefragment EPKSC (123-225)], (225-219')-disulfide with kappa fusionchain (1'-481') [humanized V-KAPPA from clone 4D5MOC-B (Homosapiens FR/Mus musculus CDR, Homo sapiens IGKJ1*01, I126>L)[11.3.9] (1'-112') -Homo sapiens IGKC*01 (113'-219') -12-mer furinlinker (proteolytic cleavage spacer from Pseudomonas exotoxin A)(220'-231') -Bougainvillea spectabilis Willd bouganin fragment(27-276 from precursor, V354'>A, D358'>A, Y364'>N, I383'>A)(232'-481')] |
| CA登记号 |
945228-49-9 |
| 分 子 式 |
C3455H5371N921O1060S18 |
| 结 构 式 |
|
| 品种类别 |
antineoplastic; |
|
